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The Double Marker Test is a prenatal screening test conducted during the first trimester of pregnancy, usually between 9 to 13 weeks. It helps assess the risk of genetic abnormalities in the fetus by measuring the levels of two important biomarkers in the mother's blood: free Beta-hCG (Human Chorionic Gonadotropin) and PAPP-A (Pregnancy-Associated Plasma Protein-A). Abnormal levels of these markers can indicate a higher likelihood of chromo****l disorders such as Down syndrome (Trisomy 21) and Edwards syndrome (Trisomy 18).
This test is particularly recommended for women who are above 35 years of age, have a family history of genetic disorders, or are undergoing high-risk pregnancies. It is often conducted alongside an NT scan (Nuchal Translucency scan) to improve accuracy in detecting potential abnormalities.
The Double Marker Test requires a simple blood sample, and results are analyzed along with factors like maternal age and ultrasound findings. It is important to note that this test is not diagnostic but a screening tool. If results indicate a higher risk, further confirmatory tests like Chorionic Villus Sampling (CVS) or Amniocentesis may be recommended. Early detection through this test helps expectant parents make informed decisions and plan necessary medical interventions for a healthier pregnancy.