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The Double Marker Test is a first-trimester prenatal screening test that helps assess the risk of chromo****l abnormalities in a developing fetus. It is particularly recommended for women over 35 years of age, those with a family history of genetic disorders, or those who have had abnormal ultrasound findings.
This test measures two important biomarkers in the mother’s blood:
- Free Beta-hCG (Human Chorionic Gonadotropin): Elevated levels may indicate a higher risk of Down syndrome (Trisomy 21).
- PAPP-A (Pregnancy-Associated Plasma Protein-A): Lower levels may be linked to Edwards syndrome (Trisomy 18) and Patau syndrome (Trisomy 13).
The Double Marker Test is typically conducted between the 9th and 13th weeks of pregnancy and is often paired with an NT (Nuchal Translucency) scan to improve the accuracy of risk assessment. While this test does not provide a definitive diagnosis, abnormal results may suggest a higher risk, leading to further confirmatory tests such as Amniocentesis or Chorionic Villus Sampling (CVS).
By identifying potential genetic abnormalities early, the Double Marker Test enables expectant parents and doctors to make well-informed decisions about pregnancy management and necessary medical interventions.
